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HOW DO COVID TESTS WORK?

COVID TEST CATGORIES

Before getting into specific methods, there are two categories of COVID tests: diagnostic and antibody. A diagnostic test is meant to tell you whether you are currently infected with SARS-CoV-2. It's the test you'd be asked to take before you go to an event, or meet with a group of people.

 

Antibody tests tell you whether you've had  COVID-19 by measuring, well, your antibodies. Antibodies are made by your body in response to a pathogen, a.k.a. something in your body that isn't meant to be there. If you've been infected with SARS-CoV-2, you'll have developed some antibodies to fight it off. Antibody tests look for COVID-specific antibodies to see whether you've had to fight off the infection before.

DIAGNOSTIC TESTS & ANTIGEN BASICS

There are two methods used in diagnostic testing: antigen and RT-qPCR. I know that antigen and antibody sound similar, and they're easy to get mixed up. The reason they sound similar is that they're related. An antigen is a small part of a pathogen (foreign body) that an antibody recognizes and holds on to. The antigen is essentially the key in the lock of the antibody, where each antibody recognizes a single, specific antigen, and is able to hold onto that antigen when the two come into contact.

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Here's an easy way to remember: B holds G. The antiBODY holds the antiGEN. If you're slightly more visual, on the right there's a picture of a guy we'll call Bruce, holding the letter G. again, B holds G. If you're a big fan of 7/11, you could remember Big Gulp. Whatever works for you. For a more accurate and scientific visualization, see directly below Bruce for what an antibody-antigen complex looks like.

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Our other diagnostic test is RT-qPCR, a.k.a. Reverse Transcriptase quantitative Polymerase Chain Reaction. Phew, I got winded just reading that! We'll get into what all of that actually means later, so we'll just establish some basic understanding for now. RT-qPCR takes virus RNA, turns it into DNA, and replicates the DNA to produce a lot of it. In a RT-qPCR test, a sample is taken from a person and put through this process. Scientists then look for new DNA generated by this process, and if they find it, they know the sample contained virus RNA, meaning the person was infected. 

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<a href="https://www.freepik.com/photos/man">Man photo created by asier_relampagoestudio - www.freepik.com</a>

Wikipedia Contributors. “Antigen.” Wikipedia, Wikimedia Foundation, 10 Mar. 2021, en.wikipedia.org/wiki/Antigen#/media/File:Antibody.svg. Accessed 21 Mar. 2021.

To learn more about each of these tests, click on any of the three tests below.

ANTIBODY TESTS

 
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              DIAGNOSTIC TESTS            

 
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Volkin, Samuel. “SARS-CoV-2 Virus.” HUB, hub.jhu.edu/2020/03/20/sars-cov-2-survive-on-surfaces/.

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